Direct current reduces wound edema after full-thickness burn injury in rats.
| Autor: | Chu CS; United States Army Institute of Surgical Research, Fort Sam Houston, Texas, 78234-6315, USA., Matylevich NP, McManus AT, Mason AD Jr, Pruitt BA Jr |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of trauma [J Trauma] 1996 May; Vol. 40 (5), pp. 738-42. |
| DOI: | 10.1097/00005373-199605000-00009 |
| Abstrakt: | Objective: To observe the effect of 4 and 40 microA direct current (DC) on edema formation after burn injury in rats. Design, Materials, and Methods: Silver-nylon wound dressings were used as either anodes (-) or cathodes (+) on 20% total body surface area full-thickness scalds in anesthetized male Sprague-Dawley rats. Untreated burned rats and rats treated with silver-nylon dressings without current were used as controls. Measurements and Main Results: Immediately applied, continuous DC reduced burn edema by 17 to 48% at different times up to 48 hours postburn (p < 0.001). Neither reversal of electrode polarity nor change in current density had any significant effect on the results of treatment. Starting treatment during the first 8 hours postburn produced the least edema accumulation, but the reduction was significant even when DC was applied 36 hours afterburn. If started immediately after injury, treatment had to be continued a minimum of 8 hours to be most effective. Conclusions: Direct electric current has a beneficial effect in reducing wound edema after burn injury. |
| Databáze: | MEDLINE |
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