| Autor: |
Schmitt CK; Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, F. Edward Hèbert School of Medicine, Bethesda, MD 20814-4799, USA., Darnell SC, O'Brien AD |
| Jazyk: |
angličtina |
| Zdroj: |
FEMS microbiology letters [FEMS Microbiol Lett] 1996 Jan 15; Vol. 135 (2-3), pp. 281-5. |
| DOI: |
10.1111/j.1574-6968.1996.tb08002.x |
| Abstrakt: |
FlgM inhibits the flagella-specific sigma factor FliA and is involved in the mouse-virulence of Salmonella typhimurium. In recent experiments, we observed that: (i) a flgM gene that could function to negatively regulate flagella synthesis was present in a variety of salmonellae; and (ii) the flgM gene derived from Salmonella species that are not normally virulent in mice could complement the S. typhimurium flgM mutant for virulence. Our results suggest that a functional flgM has been retained in most, and perhaps all, Salmonella species, regardless of the motility or virulence phenotype of the strain. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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