| Autor: |
Giron KP; Medical Science, Infectious Disease Section, Veterans Affairs Medical Center, Houston, Texas 77030, USA., Gross ME, Musher DM, Williams TW Jr, Tharappel RA |
| Jazyk: |
angličtina |
| Zdroj: |
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1995 Dec; Vol. 39 (12), pp. 2798-800. |
| DOI: |
10.1128/AAC.39.12.2798 |
| Abstrakt: |
Adding rifampin to penicillin or l-ofloxacin diminished the rate at which these antibiotics killed 21 clinical isolates isolates of Streptococcus pneumoniae in vitro. A less pronounced inhibitory effect was observed when rifampin was added to ceftriaxone. Synergy was not observed for any bacterial isolate. The in vitro demonstration of indifference or antagonism using these antibiotic combinations argues against the empirical addition of rifampin to beta-lactams or fluoroquinolones in treating serious pneumococcal infections. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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