| Autor: |
Roeling TA; Department of Anatomy and Embryology, Vrije Universiteit, Faculty of Medicine, Graduate School Neurosciences, Amsterdam, The Netherlands., Docter GJ, Voorn P, Melchers BP, Wolters EC, Groenewegen HJ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of chemical neuroanatomy [J Chem Neuroanat] 1995 Oct; Vol. 9 (3), pp. 155-64. |
| DOI: |
10.1016/0891-0618(95)00072-0 |
| Abstrakt: |
Previous immunocytochemical studies in rats have indicated that striatal dopamine depletion leads to an increase in enkephalin-immunoreactivity and a decrease in substance P-immunoreactivity in the striatum. Similar studies in primates have lead to contradictory results. In the present study changes in tyrosine hydroxylase-, met-enkephalin- and substance P-immunoreactivity were determined in the basal ganglia of 6 common marmosets Callithrix jacchus following dopamine depletion by unilateral intracerebral 6-hydroxydopamine (6-OHDA) injections using three different survival times. The non-lesioned side served as an intra-individual control. Tyrosine hydroxylase immunoreactivity was strongly reduced in the entire ipsilateral striatum. Enkephalin-immunoreactivity was increased throughout the striatum. Substance P-immunoreactivity was significantly increased in only one case in the caudate nucleus and in two cases in the putamen, while in other cases either a non-significant increase or decrease was found. Therefore, the results of the present study indicate that in marmosets dopamine has a inhibiting effect on the levels of striatal enkephalin, while its effect on substance P (SP) appears to be absent. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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