| Autor: |
Begara I; Department of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, UK., Luján L, McLaren L, Collie DD, Miller HR, Watt NJ |
| Jazyk: |
angličtina |
| Zdroj: |
Veterinary immunology and immunopathology [Vet Immunol Immunopathol] 1995 Oct; Vol. 48 (3-4), pp. 261-73. |
| DOI: |
10.1016/0165-2427(95)05443-a |
| Abstrakt: |
A model of experimental infection with EV1, a lytic British isolate of maedi-visna virus (MVV), was developed. Ten Texel sheep were allocated to two groups and inoculated by the respiratory route with different inocula. Six of the animals received 10(7.2) TCID50 (tissue culture infective dose) of EV1 strain, while four sheep were sham-inoculated with identically prepared virus-free buffer solution. Experimental infection was followed for 8 weeks post-inoculation (PI), with development of precipitating antibodies to MVV developed in the MVV-inoculated animals during the first 4 weeks PI. Transforming growth factor-beta (TGF-beta) levels, in both bronchoalveolar lavage fluid supernatant and plasma samples, were measured. Concentrations of pulmonary epithelial lining fluid (PELF) TGF-beta were calculated. TGF-beta concentrations in PELF were approximately 165-fold higher than in plasma. No significant differences in the concentrations of plasma or PELF TGF-beta, either within or between groups, were observed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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