Frequency of abnormal karyotypes among abortuses from women with and without a history of recurrent spontaneous abortion.

Autor:	Stern JJ; Grupo De Reproducción y Genetica AGN y Asociados Hospital Angeles Del Pedregal, México, D.F., México., Dorfmann AD, Gutiérrez-Najar AJ, Cerrillo M, Coulam CB
Jazyk:	angličtina
Zdroj:	Fertility and sterility [Fertil Steril] 1996 Feb; Vol. 65 (2), pp. 250-3.
DOI:	10.1016/s0015-0282(16)58079-0
Abstrakt:	Objective: To compare the frequency of chromosomal abnormalities in products of conception from women with and without a history of recurrent spontaneous abortion. Design: Retrospective analysis of prospectively collected material. Setting: Private practice at the Genetics and IVF Institute, Fairfax, Virginia and Grupo de Reproducción AGY Asociados, México City, México. Patients: Women with (n = 94) and without (n = 130) a history of recurrent spontaneous abortion who had a spontaneous abortion between January 1, 1992 and November 1, 1994. Intervention: Chromosomal analysis performed on products of conception using standard G-banding technique. Main Outcome Measure: The percentage of chromosomal abnormalities among products of conception from women with and without recurrent spontaneous abortion was compared. Results: Among products of conception from women with recurrent spontaneous abortion, 57% (54/94) had abnormal and 43% (40/94) had normal chromosome analyses. Products of conception from women without recurrent spontaneous abortion had abnormal chromosome analyses in 57% (74/130) and normal results in 43% (56/130). Conclusions: No differences in frequency of abnormal karyotype were observed in products of conception from women with recurrent spontaneous abortion compared with women without recurrent spontaneous abortion.
Databáze:	MEDLINE
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