| Autor: |
Zeeman M; U.S. Environmental Protection Agency, Health and Environmental Review Division, Washington, D.C. 20460-0001, USA., Auer CM, Clements RG, Nabholz JV, Boethling RS |
| Jazyk: |
angličtina |
| Zdroj: |
SAR and QSAR in environmental research [SAR QSAR Environ Res] 1995; Vol. 3 (3), pp. 179-201. |
| DOI: |
10.1080/10629369508234003 |
| Abstrakt: |
As testing is not required, ecotoxicity or fate data are available for approximately 5% of the approximately 2,300 new chemicals/year (26,000 + total) submitted to the US-EPA. The EPA's Office of Pollution Prevention and Toxics (OPPT) regulatory program was forced to develop and rely upon QSARs to estimate the ecotoxicity and fate of most of the new chemicals evaluated for hazard and risk assessment. QSAR methods routinely result in ecotoxicity estimations of acute and chronic toxicity to fish, aquatic invertebrates, and algae, and in fate estimations of physical/chemical properties, degradation, and bioconcentration. The EPA's Toxic Substances Control Act (TSCA) Inventory of existing chemicals currently lists over 72,000 chemicals. Most existing chemicals also appear to have little or no ecotoxicity or fate data available and the OPPT new chemical QSAR methods now provide predictions and cross-checks of test data for the regulation of existing chemicals. Examples include the Toxics Release Inventory (TRI), the Design for the Environment (DfE), and the OECD/SIDS/HPV Programs. QSAR screening of the TSCA Inventory has prioritized thousands of existing chemicals for possible regulatory testing of: 1) persistent bioaccumulative chemicals, and 2) the high ecotoxicity of specific discrete organic chemicals. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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