Catheterization of the subarachnoid space in rabbits using a Vascular Access Port.

Autor: Tissot van Patot MC; Department of Physiology, Colorado State University, Fort Collins 80523, USA., Seim HB 3rd, Tucker A
Jazyk: angličtina
Zdroj: Journal of investigative surgery : the official journal of the Academy of Surgical Research [J Invest Surg] 1995 Sep-Oct; Vol. 8 (5), pp. 371-9.
DOI: 10.3109/08941939509015383
Abstrakt: A surgical technique allowing chronic access to the subarachnoid space in unanesthetized rabbits was devised using the Vascular Access Port system. Instrumentation provides the investigator with a method of measuring intracranial pressure and sampling cerebrospinal fluid in awake rabbits. The catheter is introduced into the dorsal cervical subarachnoid space at the C4-C5 intervertebral space via dorsal laminectomy and passed cranially into the cisterna magna. The access port is subcutaneously implanted in the dorsal thoracic region between the scapulas. This system reduces the potential for infection, is not easily removed by the animal, and is relatively easy to access with minimal discomfort for the animal.
Databáze: MEDLINE