| Autor: |
Koopman-Kimenai PM; Department of Clinical Pharmacy, Academic Hospital Nijmegen Sint Radboud, The Netherlands., Vree TB, Booij LH, Dirksen R |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of clinical pharmacology and therapeutics [Int J Clin Pharmacol Ther] 1995 Aug; Vol. 33 (8), pp. 442-8. |
| Abstrakt: |
The kinetics of 20 mg nicomorphine intramuscularly were described in 8 patients under combined general and epidural anesthesia. The half-life of nicomorphine was 0.32 +/- 0.20 h (mean +/- SD) and is governed by the absorption-rather than the elimination rate. The half-life of 6-mononicotinoylmorphine (0.39 +/- 0.09 h) was identical to that of the parent compound (p = 0.29), suggesting it is directly related to the absorption rate of nicomorphine. Morphine had a half-life of 1.38 +/- 0.31 h. Morphine is subsequently metabolized into morphine-3-glucuronide and morphine-6-glucuronide. The half-life of these 2 glucuronide conjugates was about 2.6 h (p = 0.07). A glucuronide conjugate of 6-mononicotinoylmorphine was not detected. In urine only morphine and its glucuronides are found, with renal clearance values of 214 ml.min-1 for morphine and 132 ml.min-1 for the glucuronides. The bioavailability of this pharmaceutical formulation after intramuscular administration equals that of intravenous administration in surgical patients (at the same dose). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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