| Autor: |
Wellman CL; Department of Psychology, Indiana University, Bloomington 47405, USA., Logue SF, Sengelaub DR |
| Jazyk: |
angličtina |
| Zdroj: |
Behavioral neuroscience [Behav Neurosci] 1995 Oct; Vol. 109 (5), pp. 837-50. |
| DOI: |
10.1037//0735-7044.109.5.837 |
| Abstrakt: |
Maze performance and morphology of frontal cortex were assessed in young adult, middle-aged, and aged rats with and without lesions of the nucleus basalis magnocellularis. Although maze performance did not vary with age, neuron number and the thickness of superficial laminae were reduced in aged rats. Lamina II-III neurons were hypertrophied in middle-aged rats relative to both younger and older groups. At all ages, lesions significantly impaired maze performance. In young adult rats, lesions moderately reduced the size of lamina II-III neurons. This effect was more pronounced in middle-aged rats. Lesions in aged rats did not affect neuron size. The neuronal changes seen in middle-aged rats may reflect a compensatory response to the expression of other age-related neuronal changes, which may affect the ability of cortical neurons to respond to lesion-induced loss of cholinergic input. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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