Determination of glomerular filtration rate with radionuclide renography and direct urinary activity quantitation.
| Autor: | Otto AC; Department of Nuclear Medicine, University of the Orange Free State, Bloemfontein., Pretorius PH, Dunn M, Nel MG, van Aswegen A, Marais J, Lötter MG |
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| Jazyk: | angličtina |
| Zdroj: | South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde [S Afr Med J] 1995 Aug; Vol. 85 (8), pp. 770-2. |
| Abstrakt: | Objective: The direct urinary activity quantitation method is quick (approximately 40 minutes), requires only a single blood sample, is performed as part of standard renal scanning and shows high accuracy compared with 24-hour creatinine clearance. The purpose was to evaluate the practical application and accuracy of this technique at our clinic. Design: Direct urinary activity quantitation was done in patients scheduled for routine radionuclide renography and compared to standard multiple-blood-sample techniques by means of Cr-51-EDTA and Tc-99m-DTPA. Setting: Academic Medical Complex, Department of Nuclear Medicine, Universitas Hospital, Bloemfontein. Participants: Fifteen patients scheduled for routine radionuclide renography (glomerular filtration rate (GFR) determination) were voluntarily enrolled in the study. The GFRs of selected patients varied over a wide range. Possible obstructive uropathy was excluded. Main Outcome Measures: GFRs obtained by the direct urinary method were compared with GFRs determined by multisample Cr-51-EDTA and Tc-99m DTPA. Results: GFRs from the direct urinary method compared with multisample Tc-99m-DTPA showed differences from -19.85 to 22.95 ml/min with a mean of 0.2 (+/- 12.25) ml/min (r = 0.93). When compared with multisample Cr-51 EDTA, differences ranged from -34.35 to 21.05 ml/min with a mean of -4.25 (+/- 16.08) ml/min (r = 0.90). Conclusion: The direct urinary activity technique is Conclusion: The direct urinary activity technique is easily applied and highly accurate compared with previous standardised multisample radionuclide techniques for determination of GFR. |
| Databáze: | MEDLINE |
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