[Synthesis of stearoyl derivatives of proline-containing hydrophobic peptides].

Autor: Iskhakova FKh, Esipova OV, Zvonkova EN
Jazyk: ruština
Zdroj: Bioorganicheskaia khimiia [Bioorg Khim] 1995 Aug; Vol. 21 (8), pp. 596-603.
Abstrakt: Hydrophobic stearoyl derivatives of proline-containing di- and tripeptides and their deuterated analogs were synthesized. It was shown by NMR spectroscopy that cis-trans-equilibrium around an X-Pro peptide bond is displaced towards trans-conformers for compounds containing a Ste-Pro fragment as opposed to the compounds containing Boc-Pro or Gly-Pro fragments.
Databáze: MEDLINE