| Autor: |
Dorner H; Chair of Internal Medicine-Gerontology, University of Erlangen-Nürnberg, Germany., Fischer B, Seefried G, Platt D |
| Jazyk: |
angličtina |
| Zdroj: |
Gerontology [Gerontology] 1995; Vol. 41 (5), pp. 252-9. |
| DOI: |
10.1159/000213691 |
| Abstrakt: |
Plasma fibrinogen concentration and expression of mRNA encoding the gamma-chain of fibrinogen were determined in female Sprague-Dawley rats aged 10, 21 and 30 months. Both parameters increased significantly with age in a parallel fashion. Food restriction was able to reduce the age-dependent increase of both plasma concentration and gene expression to levels below young controls. On the other hand, long-term treadmill running failed to influence the plasma fibrinogen concentration. From these results we conclude that the plasma fibrinogen concentration increases with age due to an increased fibrinogen biosynthesis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
