| Autor: |
Chepurnaya OV; Department of Molecular and Radiation Biophysics, Petersburg Nuclear Physics Institute Academy of Sciences of Russia, Gatchina, Russia., Kozhin SA, Peshekhonov VT, Korolev VG |
| Jazyk: |
angličtina |
| Zdroj: |
Current genetics [Curr Genet] 1995 Aug; Vol. 28 (3), pp. 274-9. |
| DOI: |
10.1007/BF00309787 |
| Abstrakt: |
The RAD58 (XRS4) gene of Saccharomyces cerevisiae has been previously identified as a DNA repair gene. In this communication, we show that RAD58 also encodes an essential meiotic function. The spore inviability of rad58 strains is not rescued by a spo13 mutation. The rad50 mutation suppresses spore inviability of a spo13 rad58 strain suggesting that RAD58 acts after RAD50 in meiotic recombination. The rad58-4 mutation does not prevent mitotic recombination events. Haploid rad58 cells fail to carry out G2-repair of gamma-induced lesions, whereas rad58/rad58 diploids are able to perform some diploid-specific repair of these lesions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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