| Autor: |
Bailly D; Psychopathology and Alcohology Unit, University Hospital, Lille, France., Vignau J, Racadot N, Beuscart R, Servant D, Parquet PJ |
| Jazyk: |
angličtina |
| Zdroj: |
Psychiatry research [Psychiatry Res] 1993 Apr; Vol. 47 (1), pp. 57-88. |
| DOI: |
10.1016/0165-1781(93)90055-l |
| Abstrakt: |
This study investigated platelet serotonin (5-hydroxytryptamine; 5-HT) levels and the effects of different physiological and pathological factors in 108 alcoholic patients (alcohol abuse, n = 49; alcohol dependence, n = 59) and 32 healthy control subjects. Platelet 5-HT levels were determined by a fluorescent-ortho-phthalaldehyde assay. In patients, platelet 5-HT levels during withdrawal from alcohol and after 2 weeks of abstinence were significantly lower than in control subjects. Among patients, this decrease was enhanced both in alcohol-dependent patients and in patients who were depressed during the withdrawal phase, whereas lifetime impulse control disorders (mostly found in alcohol abusers) were associated with comparatively high platelet 5-HT levels (i.e., close to control subjects' values). These results, which reflect the likely biphasic effect of alcohol ingestion upon 5-HT functioning, are consistent with the dimensional 5-HT hypothesis in psychiatric disorders. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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