| Autor: |
Duckworth C; Department of Medicine, Medical College of Georgia, Augusta 30912., Fisher JF, Carter SA, Newman CL, Cogburn C, Nesbit RR, Wray CH |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 1993 Apr; Vol. 31 (4), pp. 581-4. |
| DOI: |
10.1093/jac/31.4.581 |
| Abstrakt: |
Serum and tissue samples were obtained during surgery from four diabetics with neuropathy who underwent debridement or amputation for foot infections while receiving clindamycin 600 or 900 mg iv. Clindamycin concentrations were assayed by radioimmunoassay. Clindamycin was detected in all serum and tissue samples (range: 0.04-2.8 mg/kg in tissues and 1.1-11.1 mg/L in serum). In nine of the eleven tissue samples the clindamycin concentration exceeded the MICs reported for many pathogens commonly involved in such infections. In only a single instance was the ratio of tissue to serum concentration < 0.13. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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