Lamin A/C gene and a related sequence map to human chromosomes 1q12.1-q23 and 10.

Autor: Kamat AK; Department of Biochemistry and Molecular Biology, Lederle Graduate Research Center, University of Massachusetts, Amherst., Rocchi M, Smith DI, Miller OJ
Jazyk: angličtina
Zdroj: Somatic cell and molecular genetics [Somat Cell Mol Genet] 1993 Mar; Vol. 19 (2), pp. 203-8.
DOI: 10.1007/BF01233534
Abstrakt: Lamins A and C are products of alternate splicing of one transcript from a single gene. We have isolated a partial cDNA, cE1-2, whose 800-bp sequence is 99% identical to the 3' untranslated region of the lamin A/C gene. We report here the mapping of this gene and a closely related sequence to human chromosomes 1 and 10, more specifically, to 1q12.1-q23. The localization of cE1-2 hybridizing sequences to two different chromosomes suggests that one of these loci represents an as yet unknown member of the lamin gene family, either a pseudogene or an expressed gene.
Databáze: MEDLINE