| Autor: |
Cleary PA; Biostatistics Center, George Washington University, Rockville, Maryland 20852., Beck RW, Anderson MM Jr, Kenny DJ, Backlund JY, Gilbert PR |
| Jazyk: |
angličtina |
| Zdroj: |
Controlled clinical trials [Control Clin Trials] 1993 Apr; Vol. 14 (2), pp. 123-42. |
| DOI: |
10.1016/0197-2456(93)90015-6 |
| Abstrakt: |
The Optic Neuritis Treatment Trial (ONTT) was an investigator-initiated, multi-centered, randomized, controlled clinical trial supported by cooperative agreements and grants. It was designed to evaluate the efficacy and safety of oral prednisone or intravenous methylprednisolone followed by oral prednisone as compared with oral placebo. The primary outcome measures were contrast sensitivity and visual field; secondary measures were visual acuity and color vision. Four hundred fifty-seven patients were followed for a minimum of 6 months and a maximum of 3 years. This article describes the design and the methods used to implement the ONTT. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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