| Autor: |
Killday KB; Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Ft. Pierce, Florida 34946., Longley R, McCarthy PJ, Pomponi SA, Wright AE, Neale RF, Sills MA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 1993 Apr; Vol. 56 (4), pp. 500-7. |
| DOI: |
10.1021/np50094a008 |
| Abstrakt: |
Six sesquiterpene-derived compounds, 1-6, which we call sollasins a-f, have been isolated from a deep water specimen of the sponge Poecillastra sollasi. The structures were elucidated by comparison of spectral data to related metabolites and confirmed using spectroscopic methods. The compounds inhibit the growth of the pathogenic fungi Candida albicans and Cryptococcus neoformans and the P-388 and A-549 tumor cell lines. Compounds 3 and 4 show weak inhibition of binding of [125I] angiotensin II to rat aorta smooth muscle cell membranes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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