| Autor: |
Pellicciari R; Istituto di Chimica Farmaceutica e Tecnica Farmaceutica Universita degli Studi, Perugia, Italy., Natalini B, Costantino G, Garzon A, Luneia R, Mahmoud MR, Marinozzi M, Roberti M, Rosato GC, Shiba SA |
| Jazyk: |
angličtina |
| Zdroj: |
Farmaco (Societa chimica italiana : 1989) [Farmaco] 1993 Feb; Vol. 48 (2), pp. 151-7. |
| Abstrakt: |
The design of new heterocyclic derivatives as modulatory agents at EAA receptors is described. In particular, the potent and selective activity at the NMDA receptor of trans-4-hydroxypipecolic acid-4-sulfate, as well as the neuroprotective properties of substituted thiokynurenates, a new class of competitive antagonists at the glycine site of the NMDA receptor complex, are reported. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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