| Autor: |
Buckle DR, Outred DJ, Ross JW, Smith H, Smith RJ, Spicer BA, Gasson BC |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1979 Feb; Vol. 22 (2), pp. 158-68. |
| DOI: |
10.1021/jm00188a007 |
| Abstrakt: |
The syntheses and structure--activity relationships of a number of 4-hydroxy-3-nitrocoumarins, which are both antagonists of a slow reacting substance of anaphylaxis and potent inhibitors of antigen-induced histamine release in the rat, are described. Most active among these are 7-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy(-2-hydroxypropoxy] derivatives having hydrogen or lower alkyl substituents at the C-8 position of the coumarin ring, 168, 171, 173, and 174. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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