Differential protein binding of ceftizoxime in cord versus maternal serum.

Autor: Fortunato SJ; Department of Obstetrics and Gynecology, Tulane University, School of Medicine, New Orleans, LA 70112., Welt SI, Stewart JT
Jazyk: angličtina
Zdroj: American journal of obstetrics and gynecology [Am J Obstet Gynecol] 1993 Mar; Vol. 168 (3 Pt 1), pp. 914-5.
DOI: 10.1016/s0002-9378(12)90844-3
Abstrakt: Ceftizoxime concentrations are higher in cord blood and amniotic fluid than in maternal blood. More avid binding to fetal serum proteins is a suggested mechanism. We measured ceftizoxime protein binding in fetal and maternal blood and documented significantly less protein binding to fetal proteins (21.9% vs 57.8%).
Databáze: MEDLINE