| Autor: |
Iwai SA; 2nd Department of Oral Surgery, Dental Faculty, Osaka University, Japan., Kosaka M, Nishina Y, Sumi T, Sakuda M, Nishimune Y |
| Jazyk: |
angličtina |
| Zdroj: |
Experimental cell research [Exp Cell Res] 1993 Mar; Vol. 205 (1), pp. 39-43. |
| DOI: |
10.1006/excr.1993.1055 |
| Abstrakt: |
To obtain information on the mechanism of teratocarcinoma cell differentiation, the expression of genes having a specific role in gene regulation was examined using three different methods of inducing differentiation: drug treatments with retinoic acid (RA) and sodium butyrate, and a genetic approach using ts mutants. The RAR-beta and MK genes were induced specifically by RA treatment, which indicates that these two genes are solely RA responsive. By contrast, a change in c-jun, Hox1.6, and Oct-3 gene expression was observed in all three methods of F9 cell differentiation. These findings suggest that these three genes, whether down-or up-regulated, play an important and key role during teratocarcinoma cell differentiation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
