| Autor: |
Kadomatsu K; Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892., Anzano MA, Slayter MV, Winokur TS, Smith JM, Sporn MB |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer research [Cancer Res] 1993 Apr 01; Vol. 53 (7), pp. 1480-3. |
| Abstrakt: |
To understand the molecular mechanism of carcinogenesis in androgen-dependent tumors, we have searched for new markers which are associated with this process. In normal rat prostate and seminal vesicle, sulfated glycoprotein 2 (SGP-2) messenger RNA is barely detectable. However, we have found high levels of SGP-2 expression in the epithelial component of carcinomas of the prostate and seminal vesicle after initiation with N-nitroso-N-methylurea and promotion with testosterone propionate. We have also observed induction of SGP-2 expression in epithelial cells at early stages in carcinogenesis when cytologically malignant cells first begin to appear. SGP-2 has been reported previously to be associated with a variety of models of programmed cell death (apoptosis), including the prostate following castration. Our present findings provide a novel marker for carcinogenesis in the rat prostate and seminal vesicle. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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