| Autor: |
Delb W; Universitäts-HNO-Klinik Homburg/Saar., Feilen S, Koch A, Federspil P |
| Jazyk: |
němčina |
| Zdroj: |
Laryngo- rhino- otologie [Laryngorhinootologie] 1993 Jan; Vol. 72 (1), pp. 24-7. |
| DOI: |
10.1055/s-2007-997847 |
| Abstrakt: |
The application of the potent anticancer drug cisplatin is limited by major side effects such as its ototoxicity and its nephrotoxicity. Since carboplatin has been introduced into clinical use, a platinum derivative with less pronounced ototoxicity and nephrotoxicity is available. The aim of this study was to quantify the ototoxicity of carboplatin comparing it to cisplatin using the wellknown guinea-pig model. Using morphological and functional methods it could be shown that the ototoxic damage was by far higher in a group which had received a total dose of 12 kg cisplatin/kg than in a group which had received a dosage of 90 mg carboplat/kg. Our investigations show that the ototoxic potential of cisplatin in the guinea-pig is more than 9 times higher than that of carboplatin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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