| Autor: |
Dalley BK; Division of Biological Sciences University of Missouri-Columbia 65211., Rogalski TM, Tullis GE, Riddle DL, Golomb M |
| Jazyk: |
angličtina |
| Zdroj: |
Genetics [Genetics] 1993 Feb; Vol. 133 (2), pp. 237-45. |
| DOI: |
10.1093/genetics/133.2.237 |
| Abstrakt: |
To investigate the regulation of RNA polymerase II levels in Caenorhabditis elegans, we have constructed nematode strains having one, two, or three copies of ama-1, the gene for the largest subunit of RNA polymerase II. Steady-state levels of RNA polymerase II polypeptides and solubilized enzyme activity are invariant with gene dosage, indicating regulatory compensation. However, steady-state levels of ama-1 mRNA are directly proportional to gene dosage. These results imply that RNA polymerase II levels in C. elegans are regulated post-transcriptionally. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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