| Autor: |
Okoyeh JN; Pharmacology and Clinical Pharmacy, Ahmadu Bello University, Zaria, Nigeria., Lege-Oguntoye L, Emembolu JO, Sarki U, Slotboom AB |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of tropical medicine and hygiene [J Trop Med Hyg] 1993 Feb; Vol. 96 (1), pp. 56-9. |
| Abstrakt: |
The in-vivo response of Plasmodium falciparum to a single dose of 25 mg pyrimethamine was evaluated in pregnant women in a semi-rural area of Zaria, northern Nigeria. Forty-four women were enrolled in the study and followed up for 14 days. Thirty-one (70%) of the women had cleared their parasitaemia by Day 7 and they remained parasite negative throughout the 14-day period of observation. The MPCT was 2.48 +/- 0.76 days. Thirteen (30%) of the 44 women were parasite positive either on Day 7 (7.16%) or Day 14 (6.14%) and re-treatment with a curative dose of chloroquine (25 mg kg-1 over 3 days) resulted in complete parasite clearance. Of the eight P. falciparum isolates successfully cultured from these women, seven (87.5%) were highly sensitive and one was resistant in vitro to the SDX/PYR combination. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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