| Autor: |
Nichols JE; Department of Medicine, University of Rochester School of Medicine, NY 14642., Fitzgerald TF, Roberts NJ Jr |
| Jazyk: |
angličtina |
| Zdroj: |
Vaccine [Vaccine] 1993; Vol. 11 (1), pp. 36-42. |
| DOI: |
10.1016/0264-410x(93)90337-w |
| Abstrakt: |
Interactions between influenza viruses and human macrophages were examined to detect potential mechanisms for enhanced febrile reactions previously associated with administration of an avian-human H1N1 reassortant vaccine. Cells exposed to that strain were compared with cells exposed to wild-type and cold-adapted H1H1 and H3H2 strains and an avian-human H3N2 strain. Cells exposed to the avian-human H1N1 virus showed increased synthesis of viral neuraminidase, previously reported to induce fever-producing cytokines, but no detectable increase in production of interleukin-1 beta, interleukin-6 and tumour necrosis factor-alpha measured by immunoassay, or decrease in interleukin-1 inhibitor activity by bioassay. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
