New matrix material for potential use in "reversible" vasectomy. Preliminary animal biocompatibility studies.

Autor: Carroll JC; Department of Urology, New England Medical Center Hospitals, Boston, Massachusetts., Schwaitzberg SD, Ucci AA Jr, Schlesinger RM, Lauritzen D, Sant GR
Jazyk: angličtina
Zdroj: Urology [Urology] 1993 Jan; Vol. 41 (1), pp. 34-7.
DOI: 10.1016/0090-4295(93)90240-b
Abstrakt: The biocompatibility of a new elastomeric-hydrogel matrix biomaterial for use as an intravasal occlusive device was assessed by inserting it into the vas deferens of dogs. The vas was removed and examined histologically after varying periods of time. The biomaterial resulted in total occlusion of the vas. Epithelial changes were limited to squamous metaplasia in areas adjacent to the implant. Changes in the subepithelium were minimal. This new material is biocompatible with the dog vas, and it has potential as an occlusive device for "reversible" vasectomy in men. Semen analysis studies are needed to assess the completeness and reversibility of the vasal occlusion achieved with this implant.
Databáze: MEDLINE