| Autor: |
Adamczewski JP; ICRF Clare Hall Laboratories, South Mimms, Herts, England., Gannon JV, Hunt T |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of virology [J Virol] 1993 Nov; Vol. 67 (11), pp. 6551-7. |
| DOI: |
10.1128/JVI.67.11.6551-6557.1993 |
| Abstrakt: |
In this paper we provide evidence that a fraction of large T antigen of simian virus 40 (SV40) interacts with cyclin A and p33cdk2 in both virus-infected and stably transformed cells. Immunoprecipitates of SV40 large T antigen from SV40-infected or SV40 large-T-antigen-transformed cells contain cyclin A, p33cdk2, and histone H1 kinase activity. Conversely, immunoprecipitates of cyclin A from these cells contain SV40 large T antigen. In this respect, SV40 large T antigen has properties similar to those of the E1A oncogene of adenoviruses and the E7 oncogene of human papillomaviruses. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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