| Autor: |
Maran R; Department of Medicine B, Chaim Sheba Medical Center, Tel-Hashomer, Israel., Dueymes M, Pennec YL, Casburn-Budd R, Shoenfeld Y, Youinou P |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of autoimmunity [J Autoimmun] 1993 Jun; Vol. 6 (3), pp. 379-87. |
| DOI: |
10.1006/jaut.1993.1032 |
| Abstrakt: |
We have developed isotype-specific enzyme-linked immunosorbent assays to assess anti-Ro/SSA and anti-La/SSB IgG subclasses in 31 patients with primary Sjögren's syndrome. The anti-Ro/SSA antibody production was largely but not totally restricted to IgG1, whilst the anti-La/SSB subclass distribution varied from one patient to another. IgG2 and IgG3 anti-La/SSB was more frequent in those patients with extraglandular manifestations. In addition, there were more increases in the IgG2 and IgG4 contribution to anti-La/SSB activity in the 16 DR3-positive patients than in the remaining 10. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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