| Autor: |
Malley A, Burger DR, Vandenbark AA, Frikke M, Finke P, Begley D, Acott K, Black J, Vetto RM |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer research [Cancer Res] 1979 Feb; Vol. 39 (2 Pt 2), pp. 619-23. |
| Abstrakt: |
The majority of melanoma tumor antigen activity present in melanoma extracts derived from fresh tumor tissue binds to a Sepharose-anti-beta2-microglobulin adsorbent. Removal of HLA antigens from the extracts of melanoma tissue by using a KBr flotation technique did not reduce either the tumor antigen activity of the extracts or the binding of melanoma tumor antigen (MTA) activity to the Sepharose-anti-beta2-microglobulin adsorbent. The complete blocking of MTA activity by pretreating the anti-beta2-microglobulin adsorbent with beta2-microglobulin and the lack of detectable MTA binding to a Sepharose anti-normal human serum adsorbent demonstrated the specificity of the binding of MTA to the anti-beta2-microglobulin adsorbent. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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