| Autor: |
Bernstein BH; Division of Rheumatology, Childrens Hospital Los Angeles, CA 90027., Miltenburg AM, van Laar JM, Hertzberger R, Breedveld FC |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical and experimental rheumatology [Clin Exp Rheumatol] 1993 Mar-Apr; Vol. 11 (2), pp. 209-13. |
| Abstrakt: |
Southern blot analysis of DNA from paired samples of synovial compartment (membrane and/or fluid) and peripheral blood T cells from nine children with juvenile rheumatoid arthritis (JRA) was carried out. Using a T cell receptor C beta probe, dominant TCR rearrangements were discovered in specimens from three patients: synovial fluid T cells from one, synovial fluid and synovial membrane cells from a second, and synovial membrane and peripheral blood cells from a third. The patient showing dominant bands in peripheral blood as well as in synovium was the only child in the series with systemic disease. Since non-specific T cell recruitment is likely to dilute antigen specific clones to low levels, the finding of dominant rearrangements in three of nine patients may indicate that oligoclonality is indeed a feature of JRA. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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