p53 mutations and aflatoxin B1 exposure in hepatocellular carcinoma patients from Thailand.

Ser) transversion at codon 249, and an ATC-->AAC (Ile-->Asn) transversion at codon 254. Samples from the Thai patients were analyzed for the presence of aflatoxin-liver DNA and aflatoxin-serum albumin adducts, and all but one were found negative. All the patients were genotyped for glutathione-S-transferase (GST) mu, an enzyme possibly involved in the detoxification of AFB1, and 12 out of 15 had the null genotype. In general, the level of aflatoxin-albumin adducts in sera and the prevalence of p53 mutation at codon 249 in HCC were lower than in other areas at high risk of HCC, including southern China and parts of Africa. -->
Grant Information: 5 U01 CA48409-05 United States CA NCI NIH HHS
Substance Nomenclature: 0 (DNA, Neoplasm)
9N2N2Y55MH (Aflatoxin B1)
EC 2.5.1.18 (Glutathione Transferase)
Entry Date(s): Date Created: 19930102 Date Completed: 19930113 Latest Revision: 20190708
Update Code: 20231215
DOI: 10.1002/ijc.2910530111
PMID: 8380058
Autor: Hollstein MC; Unit of Mechanisms of Carcinogenesis, International Agency for Research on Cancer, Lyon, France., Wild CP, Bleicher F, Chutimataewin S, Harris CC, Srivatanakul P, Montesano R
Jazyk: angličtina
Zdroj: International journal of cancer [Int J Cancer] 1993 Jan 02; Vol. 53 (1), pp. 51-5.
DOI: 10.1002/ijc.2910530111
Abstrakt: The prevalence and type of mutations in the p53 tumour-suppressor gene have been determined in 15 hepatocellular carcinomas (HCC) originating from Thailand. Direct sequencing of exons 5-8 revealed 2 mutations, an AGG to AGT (Arg-->Ser) transversion at codon 249, and an ATC-->AAC (Ile-->Asn) transversion at codon 254. Samples from the Thai patients were analyzed for the presence of aflatoxin-liver DNA and aflatoxin-serum albumin adducts, and all but one were found negative. All the patients were genotyped for glutathione-S-transferase (GST) mu, an enzyme possibly involved in the detoxification of AFB1, and 12 out of 15 had the null genotype. In general, the level of aflatoxin-albumin adducts in sera and the prevalence of p53 mutation at codon 249 in HCC were lower than in other areas at high risk of HCC, including southern China and parts of Africa.
Databáze: MEDLINE
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