| Autor: |
Mangiafico RA; Instituto di Clinica Medica L. Condorelli, Università di Catania, Italy., Malatino LS, Santonocito M, Spada RS, Polizzi G, Stancanelli B, Leonardi C, Tamburino G |
| Jazyk: |
angličtina |
| Zdroj: |
International angiology : a journal of the International Union of Angiology [Int Angiol] 1993 Mar; Vol. 12 (1), pp. 29-33. |
| Abstrakt: |
To investigate the effects of postural changes and upright exercise on atrial natriuretic peptide release and renin-angiotensin-aldosterone system behavior in patients with venous valvular insufficiency, plasma ANP, plasma renin activity and aldosterone were measured in 11 patients with venous disease and in 11 age-matched controls. In patients with large varicose veins and venous valvular dysfunction, standing was associated with a greater fall in circulating ANP levels (p < 0.05) and upright exercise was accompanied by a smaller rise in ANP concentrations (p < 0.05) as compared with controls. A significant (p < 0.001) inverse relationship was found between the number of venous segments with reflux and both upright and exercise plasma ANP concentrations (r = -0.91; r = -0.84, respectively). In the two groups the response of the renin-angiotensin-aldosterone system to upright position and physical stress was similar. These results suggest that a decreased atrial stretch, due to a reduced venous return, could account for the blunted ANP response to erect posture and exercise in patients with venous valvular incompetency. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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