| Autor: |
Seregin SV, Siniakov AN, Pozdniakov SG, Kozlov IuV, Sakhno LV, Leplina OIu, Nomokonova NIu |
| Jazyk: |
ruština |
| Zdroj: |
Molekuliarnaia biologiia [Mol Biol (Mosk)] 1993 Jul-Aug; Vol. 27 (4), pp. 763-72. |
| Abstrakt: |
Recombinant plasmids providing the synthesis of chimeric proteins consisting of amino acid sequences of human interleukin-2 (IL-2) and Shiga toxin cytotoxic A-subunit (ILA and AIL chimeric toxins) were constructed. The ILA and AIL chimeric toxins were shown to inhibit protein synthesis in the rabbit reticulocytes cell-free system. These chimeric toxins displayed two opposite activities of the constituent parts of their molecules on T-lymphocytes from the peripheral blood of healthy volunteers. Hybrid protein AIL (approximately 10(-6) g/ml) has caused the most significant depression of T-lymphoblast proliferation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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