| Autor: |
Charpentier A; Division of Nutritional Sciences, University of Texas, Austin 78712-1097., Groves S, Simmons-Menchaca M, Turley J, Zhao B, Sanders BG, Kline K |
| Jazyk: |
angličtina |
| Zdroj: |
Nutrition and cancer [Nutr Cancer] 1993; Vol. 19 (3), pp. 225-39. |
| DOI: |
10.1080/01635589309514254 |
| Abstrakt: |
The RRR-alpha-tocopheryl succinate form of vitamin E inhibits the proliferation of estrogen receptor-positive and estrogen receptor-negative human breast cancer cell lines in a dose-dependent manner in vitro. Analyses of cell-conditioned medium from RRR-alpha-tocopheryl succinate growth-inhibited cells revealed the presence of a potent antiproliferative activity. Characterization of the antiproliferative activity as transforming growth factor-beta (TGF-beta) was established by 1) growth inhibition of the TGF-beta-responsive Mv1Lu-CCL-64 mink lung and murine CTLL-2 cell lines, 2) combination of physical characteristics including heat stability, acid stability, and Bio-Gel P-60 column chromatography elution profile, and 3) neutralization of the antiproliferative activity in the conditioned media by antibodies specific for TGF-beta. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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