| Autor: |
Cunningham CL; Department of Medical Psychology, Oregon Health Sciences University, Portland 97201-3098., Niehus JS |
| Jazyk: |
angličtina |
| Zdroj: |
Behavioral neuroscience [Behav Neurosci] 1993 Jun; Vol. 107 (3), pp. 468-79. |
| DOI: |
10.1037//0735-7044.107.3.468 |
| Abstrakt: |
This study examined the relationship between ethanol's thermal and motivational effects in a place conditioning task. In three experiments, male albino rats were exposed to a differential conditioning procedure that paired a distinctive tactile stimulus with ethanol (1.2 or 1.8 g/kg) or lithium chloride (3 meq/kg); a different stimulus was paired with saline. Different groups were exposed to ambient temperatures (Ta) of 5 degrees, 21 degrees or 32 degrees C during each 60-min conditioning trial. Both ethanol and lithium chloride produced hypothermia and conditioned place aversion in rats conditioned at normal Ta. Exposure to high Ta reduced drug-induced hypothermia, increased activity, and decreased conditioned place aversion. Exposure to low Ta did not enhance drug-induced hypothermia or change conditioned place aversion. In general, these findings support the suggestion that the hedonic effects of ethanol and lithium chloride interact with their thermal effects. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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