| Autor: |
Dong Q; Department of Chemistry, Rutgers University, New Brunswick, NJ 08855., Blatter EE, Ebright YW, Bister K, Ebright RH |
| Jazyk: |
angličtina |
| Zdroj: |
The EMBO journal [EMBO J] 1994 Jan 01; Vol. 13 (1), pp. 200-4. |
| DOI: |
10.1002/j.1460-2075.1994.tb06249.x |
| Abstrakt: |
Myc binds to a 6 bp 2-fold symmetric DNA site: 5'-C-3A-2C-1G+1T+2G+3-3'. Using site-specific 5-bromouracil mediated photocrosslinking, we show that His336 of Myc contacts, or is close to, the thymine 5-methyl group at 2-fold symmetry-related positions -2 and +2 of the DNA site in the Myc-DNA complex. Our results strongly suggest that homologous amino acids of Myc and Max make equivalent contacts in the respective protein-DNA complexes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
