| Autor: |
Bom VJ; Department of Haemostasis, Thrombosis & Rheology, University Hospital Groningen, The Netherlands., Brügemann J, van der Schaaf W, van Wijk RT, van der Meer J |
| Jazyk: |
angličtina |
| Zdroj: |
Clinica chimica acta; international journal of clinical chemistry [Clin Chim Acta] 1993 Sep 30; Vol. 218 (2), pp. 121-9. |
| DOI: |
10.1016/0009-8981(93)90176-5 |
| Abstrakt: |
A simple enzyme immunoassay for determination of anti-streptokinase antibodies (aSKa) in plasma is described. Commercially available reagents have been used for the assay, which is calibrated with a reference preparation of aSKa containing 100 AU/ml. The assay is specific and reproducible with a variation coefficient of 4.8%. In healthy individuals a broad range of values between 4 and 291 AU/ml was observed with a large difference between the mean and median value (55 AU/ml and 27 AU/ml, respectively). Data from a study on 21 patients with myocardial infarction treated with the streptokinase derivative antistreplase suggest that a high titre of aSKa before treatment is associated with failure of thrombolytic therapy. The assay procedure can be shortened to 0.5 h to screen patients for a high aSKa level. This assay allows a more routine assessment of aSKa in the clinic. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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