| Autor: |
Kaasinen ES; Department of Surgery, Municipal Hospital, Hyvinkää, Finland., Kalliomäki PH, Alfthan OS, Timonen TT |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of urology [Br J Urol] 1993 Dec; Vol. 72 (6), pp. 897-906. |
| DOI: |
10.1111/j.1464-410x.1993.tb16293.x |
| Abstrakt: |
The activity of lymphokine (interleukin-2) activated killer (LAK) cells from 9 patients with transitional cell carcinoma (TCC) was tested against autologous, freshly purified transitional carcinoma cells. Cytotoxicity was relatively low. Bacillus Calmette-Guérin (BCG) substantially augmented both LAK activity and the cytolytic activity of non-stimulated peripheral blood mononuclear cells (PBMC) against autologous TCC when tested with 6 additional TCC patients. A similar enhancing effect of BCG was noted with leucocytes obtained from normal donors when tested against an allogenic T24 cell line. Both natural killer (NK) cells and T cells appeared to be responsible for the increased cytolytic activity caused by BCG. No cytolytic activity was noted against normal transitional epithelial cells. Sensitisation of TCC cells to the immune system may explain the clinical effects of BCG. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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