[Permeability of dialysis membranes for hepatitis-B virus: on the prophylaxis of hepatitis in a haemodialysis centre (author's transl)].

Autor: Scheiermann N, Thraenhart O, Dermietzel R, Cremer W, Kuwert EK, Graben N, Merguet P
Jazyk: němčina
Zdroj: Deutsche medizinische Wochenschrift (1946) [Dtsch Med Wochenschr] 1977 Jan 07; Vol. 102 (1), pp. 10-3.
DOI: 10.1055/s-0028-1104833
Abstrakt: Dialysis fluids of two hepatitis-Bs (HBs) antigen-positive dialysis patients were tested for hepatitis-B virus. Total dialysate volume of 5.5 litres each - as obtained on haemodialysis with the Redy-recirculation system - was concentrated by ultrafiltration and trap and rate-zonal ultracentrifugation, followed by fractionation, and purified. Electron-microscopic evidence of permeability of an intact dialysis membrane for hepatitis-B was obtained. Concentration of hepatitis-B virus was at least 10(3) to 10(4) particles per total volume. Because of the potential infectiousness of the dialysis apparatus by effective heat sterilisation after every dialysis is essential.
Databáze: MEDLINE