| Autor: |
Puchnina-Artushenko EA; Institute of Experimental Cardiology, Moscow, Russia., Ledenev AV, Ruuge EK, Muzykantov VR |
| Jazyk: |
angličtina |
| Zdroj: |
Agents and actions [Agents Actions] 1993; Vol. 39 Spec No, pp. C192-4. |
| DOI: |
10.1007/BF01972763 |
| Abstrakt: |
Hydrogen peroxide (H2O2) is an oxidative agent important in inflammation and ischemia. Neutrophils (PMNs) are a main source of H2O2 in the inflammatory focus. However, after recruitment into the inflammatory or ischemic zone of the heart, the PMN itself might serve as a target for exogenous H2O2. In the present work we found that PMNs are very resistant to the cytotoxic action of H2O2 (LD50 for PMNs is about 30-50 mM, whereas for endothelial cells it is about 200-300 microM). Unexpectedly, treatment of PMNs by H2O2 at a sublethal dose of 10 mM leads to a subsequent increase in the generation of superoxide anion in response to the chemoattractant peptide FMLP (twofold increase in O2- generation 30 min after treatment by H2O2 as compared with nontreated control cells). H2O2 itself does not induce O2- generation by PMNs. Therefore, any H2O2 that accumulated in the inflammatory or ischemic zone might alter the functional activity of PMNs and prime them to subsequent agonist activation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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