| Autor: |
Heidenreich RA; Department of Pediatrics, University of Pennsylvania, Children's Hospital of Philadelphia 19104., Mallee J, Rogers S, Segal S |
| Jazyk: |
angličtina |
| Zdroj: |
Pediatric research [Pediatr Res] 1993 Oct; Vol. 34 (4), pp. 416-9. |
| DOI: |
10.1203/00006450-199310000-00006 |
| Abstrakt: |
To assess the role of genetic regulation as a modulating factor in the variability of rat tissue galactose-1-phosphate uridyltransferase (GALT) sp act, we have determined steady state GALT mRNA and sp act in rat liver during postnatal development. Steady state GALT mRNA levels increase from birth to d 5 and subsequently decrease toward adult levels. GALT sp act mirrors the mRNA pattern. A survey of steady state mRNA and GALT sp act of several adult rat tissues revealed marked tissue differences with a good correlation of the two parameters. Liver had the highest GALT mRNA and sp act; kidney, ovary, and heart had similar but lower mRNA and sp act; skeletal muscle and testes had the least GALT mRNA and enzyme sp act. These findings suggest that genetic regulation is important in the variable expression of GALT tissue sp act. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
