| Autor: |
Verzijl JM; Department of Hospital Pharmacy, Central Military Hospital, Utrecht, The Netherlands., Joore HC, van Dijk A, Wierckx FC, Savelkoul TJ, Glerum JH |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of toxicology. Clinical toxicology [J Toxicol Clin Toxicol] 1993; Vol. 31 (4), pp. 553-62. |
| DOI: |
10.3109/15563659309025760 |
| Abstrakt: |
Prussian blue salts are used in clinical practice as an antidote for the treatment of humans contaminated with radioactive cesium. A decomposition product of these Prussian blue salts may be the highly toxic cyanide. A method to simulate gastrointestinal cyanide-release was applied to four different Prussian blue salts: K3Fe[Fe(CN)6], Fe4[Fe(CN)6]3, NH4Fe[Fe(CN)6] (pur. and unpur.). Cyanide-release was higher in artificial gastric juice than in water and artificial intestinal juice. Under all conditions cyanide-release from Fe4[Fe(CN)6]3 was the lowest. Since Fe4[Fe(CN)6]3 also binds more cesium, it appears to be the most suitable Prussian blue salt for use as an antidote after radiocesium contamination in humans. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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