The synthesis of alternating alpha,beta-oligodeoxyribonucleotides with alternating (3'-->3')- and (5'-->5')-internucleotic linkages as potential therapeutic agents.
| Autoři: | Koga M; Division of Hematologic Products, Food and Drug Administration, Bethesda, MD 20892., Geyer SJ, Regan JB, Beaucage SL |
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| Zdroj: | Nucleic acids symposium series [Nucleic Acids Symp Ser] 1993 (29), pp. 3-4. |
| Způsob vydávání: | Journal Article |
| Jazyk: | English |
| Informace o časopise: | Publisher: Oxford University Press Country of Publication: England NLM ID: 8007206 Publication Model: Print Cited Medium: Print ISSN: 0261-3166 (Print) Linking ISSN: 02613166 NLM ISO Abbreviation: Nucleic Acids Symp Ser Subsets: MEDLINE |
| Imprint Name(s): | Publication: London : Oxford University Press Original Publication: [London] ; Information Retrieval Ltd., c1979-c2000. |
| Výrazy ze slovníku MeSH: | Oligonucleotides, Antisense/*chemical synthesis, Base Sequence ; Gene Products, tat/genetics ; Genes, tat ; HIV-1/drug effects ; HIV-1/genetics ; Molecular Sequence Data ; Nucleic Acid Denaturation ; Oligonucleotides, Antisense/pharmacology ; tat Gene Products, Human Immunodeficiency Virus |
| Abstrakt: | A simplified synthesis of alpha-2'-deoxyribonucleoside derivatives has been developed and the solid-phase preparation of antisense alpha,beta-oligodeoxyribonucleotides with alternating (3'-->3')- and (5'-->5')-internucleotidic phosphodiester linkages, targeted against HIV-1 tat mRNA, has been accomplished. Hybridization properties of these oligonucleotide analogues have been investigated. |
| Gene Symbol: | Tat |
| Substance Nomenclature: | 0 (Gene Products, tat) 0 (Oligonucleotides, Antisense) 0 (tat Gene Products, Human Immunodeficiency Virus) |
| Entry Date(s): | Date Created: 19930101 Date Completed: 19931228 Latest Revision: 20071115 |
| Update Code: | 20240829 |
| PMID: | 8247779 |
| Autor: | Koga M; Division of Hematologic Products, Food and Drug Administration, Bethesda, MD 20892., Geyer SJ, Regan JB, Beaucage SL |
| Jazyk: | angličtina |
| Zdroj: | Nucleic acids symposium series [Nucleic Acids Symp Ser] 1993 (29), pp. 3-4. |
| Abstrakt: | A simplified synthesis of alpha-2'-deoxyribonucleoside derivatives has been developed and the solid-phase preparation of antisense alpha,beta-oligodeoxyribonucleotides with alternating (3'-->3')- and (5'-->5')-internucleotidic phosphodiester linkages, targeted against HIV-1 tat mRNA, has been accomplished. Hybridization properties of these oligonucleotide analogues have been investigated. |
| Databáze: | MEDLINE |
| Externí odkaz: |
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