| Autor: |
Kelvin DJ; Laboratory of Immunoregulation, Frederick Cancer Research and Development Center, Maryland 21702., Michiel DF, Johnston JA, Lloyd AR, Sprenger H, Oppenheim JJ, Wang JM |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of leukocyte biology [J Leukoc Biol] 1993 Dec; Vol. 54 (6), pp. 604-12. |
| DOI: |
10.1002/jlb.54.6.604 |
| Abstrakt: |
Chemokines are pro-inflammatory molecules with a diverse array of biological and biochemical functions. These molecules induce the migration of a number of leukocyte subsets including monocytes, neutrophils, and T-cells. The recent cloning of the IL-8, GRO, and MIP-1 alpha chemokine receptors revealed that these glycoproteins belong to the serpentine family of seven transmembrane G-protein-coupled receptors. Other members of this family include the chemotactic receptors for fMLP and C5a, indicating that a common pathway for eliciting the directional migration of leukocytes is probably transduced via G proteins. Ligand binding to chemokine receptors is complex, featured by multiple chemokines binding to a single receptor and multiple receptors binding a specific ligand. Future directions in this field appear to be focused on the cloning of novel receptors and the identification of ligands for orphaned receptors. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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