| Autor: |
Santoian EC; Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, D.C., Thomas G, Angerio AD, Kot PA, Ramwell PW |
| Jazyk: |
angličtina |
| Zdroj: |
Angiology [Angiology] 1993 Nov; Vol. 44 (11), pp. 897-901. |
| DOI: |
10.1177/000331979304401108 |
| Abstrakt: |
Hydroxylamine is a natural product of cellular metabolism that possesses vasodilating properties similar to those of endothelium-derived relaxing factor (EDRF). In the rodent pulmonary circulation preconstricted with the endoperoxide analog U-46619, hydroxylamine relaxed the vasculature in a concentration-dependent manner. Blockade of the hydroxylamine vasodilator response by methylene blue indicated that the mechanism of vasorelaxation is similar to that of EDRF. In this preparation, hydroxylamine is a more potent vasodilator than nitroglycerin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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