| Autor: |
Huang M; Department of Medicine, University of Calgary, Alberta, Canada., Shirahase H, Rorstad OP |
| Jazyk: |
angličtina |
| Zdroj: |
Peptides [Peptides] 1993 Jul-Aug; Vol. 14 (4), pp. 755-62. |
| DOI: |
10.1016/0196-9781(93)90109-t |
| Abstrakt: |
The pharmacological properties of the pituitary adenylate cyclase activating peptides (PACAPs) and vasoactive intestinal peptide (VIP) were compared using: (i) relaxation of vascular and gastric smooth muscle in vitro, and (ii) radioligand binding to membrane preparations of a variety of tissues. Vasoactive intestinal peptide and PACAP-27 were similarly potent in relaxing rat mesenteric arteries, porcine coronary arteries, and rat gastric smooth muscle, whereas PACAP-38 was either more or less potent than the other two peptides depending on the tissue model. Cross-desensitization to relaxation and radioligand binding studies of porcine coronary arteries suggested that VIP and the PACAPs interact with a common receptor in this tissue. A PACAP-preferring receptor with low affinity for VIP was identified in radioligand binding studies of rat brain and anterior pituitary. A second, nonselective, receptor that binds VIP and both PACAPs with high affinity was observed in preparations of rat and porcine arteries and rat lung, liver, brain, and anterior pituitary. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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