| Autor: |
Suzutani T; Division of Virology, National Institute for Medical Research, Mill Hill, London, U.K., Machida H, Honess RW |
| Jazyk: |
angličtina |
| Zdroj: |
Microbiology and immunology [Microbiol Immunol] 1993; Vol. 37 (6), pp. 511-3. |
| DOI: |
10.1111/j.1348-0421.1993.tb03244.x |
| Abstrakt: |
The mechanism of the inhibitory action of 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl) uracil triphosphate (BV-araUTP) on DNA synthesis by Escherichia coli DNA polymerase I Klenow fragment was studied. Acting as a chain terminator, BV-araUTP inhibited DNA synthesis by Klenow fragment more effectively than 2',3'-dideoxythymidine triphosphate (ddTTP). However, the incorporation sites of BV-araU monophosphate were restricted at consecutive dTMP sequence whereas ddTMP was incorporated at every dTMP site. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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